Manchester NMR Methodology Group

Summary:
GEMSTONE, Gradient-Enhanced Multiplet-Selective Targeted-Observation NMR Experiment, is a method for selecting one signal from a group of overlapping mulitplet signals. Here, GEMSTONE-NOESY allows unambiguous interpretation of the NOESY spectra and can aid in the assignment of stereochemistry.

Downloads:
Bruker pulse sequences:
GEMSTONE-NOE (right click and chose 'save ... as')

Example data:
GEMSTONE and GEMSTONE-NOE repository

Pulse Sequence Diagrams:

References:

Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets
Kiraly P, Kern N, Plesniak MP, Nilsson M,Procter DJ, Morris GM, Adams RW.
Angew. Chem. Int. Ed., 2021, 60, 666-669.

Please note that copyright restrictions prevent us from placing the pdf files on our website, however, all articles are published open access and can be downloaded from the respective publishers.