19F DOSY NMR analysis for spin systems with nJFF couplings

Title19F DOSY NMR analysis for spin systems with nJFF couplings
Publication TypeJournal Article
Year of Publication2014
AuthorsDal Poggetto, G, Favaro DC, Nilsson M, Morris GA, Tormena CF
JournalMagnetic Resonance in Chemistry
Start Page172
Pagination172 - 177
Date Published01/2014

DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as 19F spectra are typically very sparse. Here, we demonstrate the use of a modified 19F DOSY experiment (on the basis of the Oneshot sequences) for various fluorinated benzenes. For compounds with significant nJFF coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This investigation highlights 19F DOSY as a valuable and robust method for analysis of molecular systems containing fluorine atoms even where there are large fluorine–fluorine couplings.

Short TitleMagn. Reson. Chem.