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A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

Mon, 03/14/2011 - 12:22 — ralph
TitleA diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles
Publication TypeJournal Article
Year of Publication2002
AuthorsBilia, AR, Bergonzi MC, Vincieri FF, Lo Nostro P, Morris GA
JournalJournal of Pharmaceutical Sciences
Volume91
Pagination2265-2270
ISBN Number0022-3549
Accession NumberWOS:000178107600017
Abstract

Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. (C) 2002 Wiley-Liss, Inc.
URLhttp://apps.isiknowledge.com/UA_GeneralSearch_input.do?product=UA&search_mode=GeneralSearchWOS:000178107600017