<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mordi, M. N.</style></author><author><style face="normal" font="default" size="100%">Pelta, M. D.</style></author><author><style face="normal" font="default" size="100%">Boote, V.</style></author><author><style face="normal" font="default" size="100%">Morris, Gareth A.</style></author><author><style face="normal" font="default" size="100%">Barber, Jill</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acid-catalyzed degradation of clarithromycin and erythromycin B: A comparative study using NMR spectroscopy</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Medicinal Chemistry</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%"><Go to ISI>://WOS:000085249200016</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">43</style></volume><pages><style face="normal" font="default" size="100%">467-474</style></pages><isbn><style face="normal" font="default" size="100%">0022-2623</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clarithromycin degrades by a different mechanism and much more slowly. We have studied the pathway and kinetics of the acid-catalyzed degradation of clarithromycin and of erythromycin B, a biosynthetic precursor of erythromycin A which also has good antibacterial activity, using H-1 NMR spectroscopy. Both drugs degrade by loss of the cladinose sugar ring and with similar rates of reaction. These results suggest that erythromycin B has potential as an independent therapeutic entity, with superior acid stability compared with erythromycin A and with the advantage over clarithromycin of being a natural product.</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000085249200016</style></accession-num><notes><style face="normal" font="default" size="100%">Times Cited: 21</style></notes></record></records></xml>