@article {195,
	title = {Acid-catalyzed degradation of clarithromycin and erythromycin B: A comparative study using NMR spectroscopy},
	journal = {Journal of Medicinal Chemistry},
	volume = {43},
	number = {3},
	year = {2000},
	note = {Times Cited: 21},
	pages = {467-474},
	abstract = {One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clarithromycin degrades by a different mechanism and much more slowly. We have studied the pathway and kinetics of the acid-catalyzed degradation of clarithromycin and of erythromycin B, a biosynthetic precursor of erythromycin A which also has good antibacterial activity, using H-1 NMR spectroscopy. Both drugs degrade by loss of the cladinose sugar ring and with similar rates of reaction. These results suggest that erythromycin B has potential as an independent therapeutic entity, with superior acid stability compared with erythromycin A and with the advantage over clarithromycin of being a natural product.},
	isbn = {0022-2623},
	url = {<Go to ISI>://WOS:000085249200016},
	author = {Mordi, M. N. and Pelta, M. D. and Boote, V. and Morris, Gareth A. and Barber, Jill}
}
