@article {320, title = {19F DOSY NMR analysis for spin systems with nJFF couplings}, journal = {Magnetic Resonance in Chemistry}, volume = {52}, year = {2014}, month = {01/2014}, pages = {172 - 177}, chapter = {172}, abstract = {DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as 19F spectra are typically very sparse. Here, we demonstrate the use of a modified 19F DOSY experiment (on the basis of the Oneshot sequences) for various fluorinated benzenes. For compounds with significant nJFF coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This investigation highlights 19F DOSY as a valuable and robust method for analysis of molecular systems containing fluorine atoms even where there are large fluorine{\^a}{\texteuro}{\textquotedblleft}fluorine couplings.}, doi = {10.1002/mrc.4047}, author = {Dal Poggetto, Guilherme and Favaro, Denize C. and Nilsson, M and Morris, Gareth A. and Tormena, Claudio F.} }